Bioactive Factors in Breastmilk
Composition of Human Milk Bioactive Factors in Breastmilk

Bioactive Factors in Breastmilk

Breastmilk is a complex biological fluid containing over 200 ‘living’, active components, many of which are known to complement the newborn’s immature immune system. These bioactive factors provide nutrition, fight pathogens, reduce inflammation, promote the establishment of a healthy gut microbiome, and facilitate growth and maturity of the immune system1,2,4.

The following are examples of bioactive factors in these varied roles:




  1. Andreas NJ, Kampmann B, Mehring Le-Doare K. Human Breast milk: A review on its composition and bioactivity Early Human Development 91 (2015) 629-635 p. 629-635
  2. Chatterton DE, Nguyen DN, Bering SB, Sangild PT. Anti-inflammatory mechanisms of bioactive milk proteins in the intestine of newborns. Int J Biochem Cell Biol (2013) 45(8):1730–47
  3. Legrand D. Overview of lactoferrin as a natural immune modulator J. Pediatr (2016) 173(Suppl) S10
  4. Lonnerdal B. Bioactive proteins in breastmilk J of Paediatrics and Child Health 49(suppl1) 2013 1-7
  5. Plaza-Diaz J, Fontana L, Gil A. Human Milk Oligosaccharides and Immune System Development Nutrients 2018, 10, 1038